GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
نویسندگان
چکیده
منابع مشابه
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Pyroptosis is a lytic type of cell death that is initiated by inflammatory caspases. These caspases are activated within multi-protein inflammasome complexes that assemble in response to pathogens and endogenous danger signals. Pyroptotic cell death has been proposed to proceed via the formation of a plasma membrane pore, but the underlying molecular mechanism has remained unclear. Recently, ga...
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Pyroptosis is a lytic type of programmed cell death that is initiated in response to pathogenor host-derived perturbations of the cytosol. It is characterized by cell swelling, lysis, and the release of cytoplasmic content; thus restricting the replication of intracellular pathogens and attracting effector cells of the immune system. The name pyroptosis derives from the Greek pyro (fire or feve...
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Pyroptosis is a form of cell death important in defenses against pathogens that can also result in a potent and sometimes pathological inflammatory response. During pyroptosis, GSDMD (gasdermin D), the pore-forming effector protein, is cleaved, forms oligomers, and inserts into the membranes of the cell, resulting in rapid cell death. However, the potent cell death induction caused by GSDMD has...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2016
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.201694696